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Figure 1
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Figure 1
Figure 1. Transcriptome profiling in mct8−/− larvae. (A) Differentially expressed genes in 6 days post-fertilization (dpf) mct8−/− and wild-type (WT) sibling larvae (n = 3 batches for each genotype). Green vertical lines differentiate between significant and insignificant expressed genes. Blue and red dots mark down-regulated and up-regulated genes (1 < log2 [fold change] < 1, adjusted p-value (p-adj) < 0.05), respectively. Black dots mark insignificant expressed genes. Orange circles mark genes validated by qRT-PCR. (B) Representative enriched gene pathways in mct8−/− larvae. The red vertical line marks the threshold of significantly enriched pathways (p-adj ≤ 0.05). (C) Normalized reads count of four differentially expressed genes selected from the enriched vision pathways shown in B. X-axis represents the sample number in each genotype. (D) Relative gene expression of selected genes was quantified using qRT-PCR and normalized against actb (n = 5 batches of larvae for each group). Statistical significance determined by t-test: two-sample. ** p < 0.01, **** p < 0.0001.
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Full text @ Int. J. Mol. Sci.