ZFIN Image: van Wijk et al., 2020, FIGURE 6

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Figure Caption

FIGURE 6

Observed and model‐based prediction of the bacterial burden after isoniazid treatment in individual zebrafish larvae infected with Mycobacterium marinum. The bacterial burden as log₁₀‐transformed fluorescent pixel count is shown over treatment time of 50 h at isoniazid doses in the external treatment medium of 0.25×, 0.5×, 1×, 2×, and 5‐fold MIC, in addition to control. Symbols represent observed data (at least n = 17 individual larvae, measured daily), and lines connect model predictions. Biological variability as quantified by the model is relatively large in contrast to experimental variability (see Figure S3 for individual predictions)

Acknowledgments

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