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Figure 7

Evaluating INS signaling in VDD liver and AT. (A,B) VDD fish had significantly elevated expression of insig1, insig2, with a significant decrease in cidec in liver 6 mpf, indicating sustained INS signaling contrary to also having significantly elevated expression of cish, socs2, and socs3b, suppressors of cytokine signaling thought to shut down the INS signaling cascade. (C) Downregulation of insig1 and cidec in VDD AT 6 mpf.

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