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Fig. 2
Perlecan expression during optic fissure formation and fusion. A) WISH for zebrafish perlecan at 24, 48, 56 and 65hpf. Perlecan expression is observed in the lens and the optic fissure from 24 to 65 hpf (yellow arrow heads). B) Examining WISH in isolated zebrafish eyes at 24, 48, 56 and 65hpf indicates that perlecan expression persists in the optic fissure (yellow arrow heads) up to 65hpf.
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Reprinted from Developmental Biology, 452(1), Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K., Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling, 43-54, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.