Gene

hspg2

ID

ZDB-GENE-080807-4

Name

heparan sulfate proteoglycan 2

Symbol

hspg2 Nomenclature History

Previous Names

perlecan (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in several processes, including blood vessel endothelial cell migration; endothelial cell proliferation; and skeletal muscle tissue development. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Is expressed in several structures, including axial vasculature; immature eye; intestine; trunk; and trunk musculature. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hspg2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Schwartz-Jampel syndrome 1	Alliance	Schwartz-Jampel syndrome, type 1	255800
Silverman-Handmaker type dyssegmental dysplasia	Alliance	Dyssegmental dysplasia, Silverman-Handmaker type	224410

Associated With hspg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000034	Laminin IV
Domain	IPR000082	SEA domain
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR051170	Neural and epithelial cell adhesion domain-containing protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding domain	EGF-like domain	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Immunoglobulin V-set domain	Laminin G domain	Laminin IV	Laminin-type EGF domain	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Neural and epithelial cell adhesion domain-containing protein	SEA domain
UniProtKB:A0A8M3ANS4 InterPro	3554
UniProtKB:A0A8M9PWW1 InterPro	3691
UniProtKB:A0A8M9PTK3 InterPro	3685
UniProtKB:A0A8M9P5I6 InterPro	3682
UniProtKB:A0A8M9PFI3 InterPro	3681
UniProtKB:A0A8M9PFI8 InterPro	3502
UniProtKB:A0A8M9P5J1 InterPro	3503
UniProtKB:A0A8M3ANR9 InterPro	3700
UniProtKB:A0A8M9PL79 InterPro	3675
UniProtKB:A0A8M9PWW5 InterPro	3658
UniProtKB:A0A8M3AYK3 InterPro	3689
UniProtKB:A0A8M9PTJ8 InterPro	3700
UniProtKB:A0A8M9P5I3 InterPro	3695
UniProtKB:A0A8M3B691 InterPro	3582
UniProtKB:A0A8M9PWV8 InterPro	3701
UniProtKB:A0A8M3AN20 InterPro	3604
UniProtKB:A0A8M3AVI2 InterPro	3688
UniProtKB:A0A8M9PFH8 InterPro	3692

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hspg2-201 (1) Ensembl	Ensembl	10,260 nt	Select Tool ZFIN BLAST
mRNA	hspg2-202 (1) Ensembl	Ensembl	10,194 nt	Select Tool
mRNA	hspg2-203 (1) Ensembl	Ensembl	10,833 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hspg2	polyclonal	hspg2		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations