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Fig. 4
Nidogen expression during optic fissure formation and fusion. A) WISH for zebrafish nidogen (nid) genes nid1a, nid1b, nid2a and nid2b at 24, 36 and 48hpf. At 24 and 36hpf nid1a, nid1b and nid2a were all expressed in the optic fissure (yellow arrow heads). Nid2b lack retinal expression between 24 and 48hpf. B) WISH time course for nid1a, 1b and 2a expression in the optic fissure (yellow arrow heads). Expression of nid1a and 2a is absent from the fissure by 48hpf, while nid1b persists past 48hpf but is absent by 56hpf.
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Reprinted from Developmental Biology, 452(1), Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K., Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling, 43-54, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.