Gene

nid2a

ID

ZDB-GENE-030827-2

Name

nidogen 2a (osteonidogen)

Symbol

nid2a Nomenclature History

Previous Names

nid2
chunp382
fb77a09
fc18d04
im:7144424
wu:fb77a09
wu:fc18d04

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Acts upstream of or within closure of optic fissure and fin regeneration. Predicted to be located in extracellular region and membrane. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including axis; digestive system; head mesenchyme; nervous system; and pectoral fin bud. Orthologous to human NID2 (nidogen 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144424 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nid2a Human Ortholog

No data available

Associated With nid2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR003886	NIDO domain
Domain	IPR006605	G2 nidogen/fibulin G2F
Domain	IPR024731	EGF domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR051950	Developmental regulator and protease inhibitor
Homologous_superfamily	IPR009017	Green fluorescent protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000033	LDLR class B repeat

Domain Details Per Protein

Protein	Length	Developmental regulator and protease inhibitor	EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	G2 nidogen/fibulin G2F	Green fluorescent protein	Growth factor receptor cysteine-rich domain superfamily	LDLR class B repeat	NIDO domain	NOTCH1 EGF-like calcium-binding domain	Six-bladed beta-propeller, TolB-like	Thyroglobulin type-1	Thyroglobulin type-1 superfamily
UniProtKB:A0A8M2BH70 InterPro	1804
UniProtKB:A0A8M2BH21 InterPro	1576
UniProtKB:A0A8M2BH48 InterPro	1424
UniProtKB:A0A8M2BH51 InterPro	1728
UniProtKB:A0A8M9PEL7 InterPro	1728
UniProtKB:A0A8M2BHK2 InterPro	1652
UniProtKB:A0A8M6YTZ1 InterPro	1576

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nid2a-201 (1) Ensembl	Ensembl	773 nt	Select Tool ZFIN BLAST
mRNA	nid2a-202 (1) Ensembl	Ensembl	5,230 nt	Select Tool ZFIN BLAST
mRNA	nid2a-203 (1) Ensembl	Ensembl	814 nt	Select Tool ZFIN BLAST
mRNA	nid2a-204 (1) Ensembl	Ensembl	649 nt	Select Tool ZFIN BLAST
mRNA	nid2a-205 (1) Ensembl	Ensembl	423 nt	Select Tool ZFIN BLAST
mRNA	nid2a-206 (1) Ensembl	Ensembl	838 nt	Select Tool ZFIN BLAST
mRNA	nid2a-207 (1) Ensembl	Ensembl	728 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations