ZFIN Image: Yang et al., 2018, Fig. S10

Image

Figure Caption

Fig. S10

Caspy2 is critical for lethal sepsis in zebrafish larvae.

(a-c) Controlmorpholino oligonucleotide (MO) or caspy2-MO zebrafish larvae at 5 dpf were immersed in 100 μg/ml of LPS. (a) Survival was then monitored for 72 hpi. Results are representative of at least three independent experiments. ** p < 0.01 (log-rank). (b) Distinct pathologies associated with lethal dose of LPS. Pericardial edema (red arrow); Fin erosion and ulceration (black arrow); Protrusions on the trunk or tail regions (white arrow). Results are representative of at least three independent experiments. (c) RT-PCR analysis of the specified cytokine transcripts at the indicated time points in control- and caspy2-MO larvae. Each bar represents mean results SEM from 3-4 pools of 15 larvae. RT-PCR for each pool was carried out using technical duplicates. *p < 0.05, **p < 0.01 (t-test).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.