ZFIN Image: Madelaine et al., 2018, Fig. 5

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Figure Caption

Fig. 5

CNE1 regulates MIR-9-2/miR-9-5 expression. (A) Schematic of the zebrafish genomic region containing pre-miR-9-5 and CNE1. pre-miR-9-5 and CNE1 are intronic in si:ch211-202e12.3, a long non-coding RNA. Three transcription starts (TSS, green arrows), host and intronic, are used for pri-miR-9-5 transcription (46). (B–F) Whole-mount ISH against host and intronic pri-miR-9-5s (probe 1 and 2, respectively), pre-miR-9-5 (probe 3), tmem161b or mef2c in control and ΔCNE1 larvae at 72 hpf. The expression of pri- and pre-miR-9-5, but not tmem161b and mef2c, is reduced in the brain of homozygous ΔCNE1 mutants. Dorsal view of the brain with anterior up. Scale bars: 100 μm.

Acknowledgments

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