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Fig. S10
EGFR inhibition blocks cardiomyocyte proliferation in WT hearts (A) Dose response of AG1478 in WT hearts on cardiomyocyte proliferation. Mef2c and PCNA immunostaining in WT hearts at 7 dpa injected with DMSO (n=15), 1 μM (n=3), 5 μM (n=5), 10 μM (n=9), and 50 μM (n=4) of AG1478. (B) Quantification of cardiomyocyte proliferation after injection of AG1478. 5, 10 and 50 μM of AG1478 reduced cardiomyocyte proliferation in WT hearts. **p<0.01 One-way ANOVA. Scale bars, 100 μm.
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