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Fig. S4
VTA formation in larvae treated with different small-molecule inhibitors. (A–H) 152 hpf Tg(kdrl:ras-mcherry) larval trunk vasculature after treatment with DMSO (A), SB203580 (B), PF573228 (C), U73122 (D), SL327 (E), SU6656 (F), SH-6 (G), and wortmannin (H) from 80 to 152 hpf. SH-6 and wortmannin treatments significantly inhibited VTA formation (yellow arrows). (Scale bar, 100 µm.) (I) Quantification of the average number of somites with VTAs for the experiments shown in A–H (20 somites examined per animal). Values represent means ± SEM (***P < 0.001 by ANOVA followed by Tukey’s HSD test).
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