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Fig. 3
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Fig. 3
In situ validation of microarray hits whose expression is increased in RA-treated embryos and reduced in antagonist-treated embryos. Dorsal views of eight selected microarray hits (blue) and egr2b (red) in situ at 11 hpf. Anterior is to the left in all panels. Column i: control (DMSO) treated; ii: 10 µM DEAB (RA synthesis antagonist) treated; iii: 0.33 µM RA-treated. The numbers in the upper right corners refer to the fold-change in expression level identified on the microarray under the corresponding conditions.
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Reprinted from Developmental Biology, 338(1), Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B., Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism, 1-14, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.