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Fig. S7
Disruption of autophagy in ttis450 larvae results in severe oedema. Upon microinjection into the yolk of 1–4 cell WT and ttis450 zebrafish embryos, an atg5-targeted MO (1 ng) produces severe oedema around the organs of ttis450 larvae at 120 hpf (D), while WT larvae are unaffected (C). WT and ttis450 larvae injected at the 1–4 cell stage with vehicle (A, B) are also unaffected.
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