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Fig. S7
Time-lapse images of endocardial formation in etsrp:GFP control and CyAtreated smo morphant embryos.
Embryos were imaged starting from the 11-12-somite stage. Dorsal view of the cranial region, anterior is up. Etsrp:GFP-expression labels vascular endothelial, myeloid and endocardial lineages that originate primarily in the midbrain organizing center (MOC, arrowheads). Note that MOC formation is not significantly affected in CyA+smo MO embryos (0 min). Endocardial progenitors (arrow) migrate to the midline in wt embryos while this migration is largely absent in CyA+smo morphants.
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Reprinted from Developmental Biology, 361(2), Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S., Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish, 377-91, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.