ZFIN Image: Liu et al., 2011, Fig. 3

Image

Figure Caption

Fig. 3

Kcnq1 knockdown in zebrafish embryos causes glomerular abnormalities.

(A–E) Zebrafish embryos injected with control morpholino show normal glomerular and tubular morphology, as shown by in situ hybridization for the global kidney marker pax2a (A, inset showing lower-magnification image, with staining in both glomerulus and tubules), the podocyte markers wt1a (B) and nephrin (C), and the proximal and distal tubular markers slc20a1a (D) and slc12a3 (E). (F–J) Injection of the kcnq1 antisense morpholino, targeting the ATG site of the gene, at the one-cell stage results in significant changes in glomerular gene expression (F–H). No changes were observed in the proximal tubule (I) or the distal tubule (J).

Figure Data

Expression / Labeling details

Acknowledgments

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