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Fig. 4 Gain of FoxA2 or FoxA3 function enlarges the axial mesoderm territory. Analysis of the axial mesoderm territory at midgastrula stage with two combinations of prechordal plate (red)/notochord (blue) markers, gsc/flh (A–D) and hgg1/shh (E–H). Embryos injected with foxA3 RNA present an enlargement of flh (B–D) and shh (F–H) expression domains compared to wild-type (A and E). When the axial mesoderm is massively enlarged, it splits in two distinct axes (arrow in D). Dorsal views, anterior up.
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Reprinted from Developmental Biology, 350(2), Dal-Pra, S., Thisse, C., and Thisse, B., FoxA transcription factors are essential for the development of dorsal axial structures, 484-495, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.