Gene

ctslb

ID

ZDB-GENE-980526-285

Name

cathepsin Lb

Symbol

ctslb Nomenclature History

Previous Names

catL
cstlb (1)
ctsl1b
ctsl
cathepsin L
cb15 (1)
hatching gland 1 (1)
hgg1 (1)
wu:fb30g09 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of apoptotic signaling pathway; positive regulation of peptidase activity; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Located in extracellular region. Is expressed in several structures, including hatching gland; hatching gland cell; hypoblast; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).

Genome Resources

Note

This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.

Comparative Information

Expression

All Expression Data

170 figures from 112 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb15 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctslb Human Ortholog

No data available

Associated With ctslb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR013201	Cathepsin propeptide inhibitor domain (I29)
Domain	IPR039417	Papain-like cysteine endopeptidase
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Cathepsin propeptide inhibitor domain (I29)	Cysteine peptidase, asparagine active site	Cysteine peptidase, cysteine active site	Cysteine peptidase, histidine active site	Papain-like cysteine endopeptidase	Papain-like cysteine peptidase superfamily	Peptidase C1A	Peptidase C1A, papain C-terminal
UniProtKB:A7MCR8 InterPro	335
UniProtKB:P79722 InterPro	336
UniProtKB:A7MCR7 InterPro	336
UniProtKB:A8E587 InterPro	336
UniProtKB:A7MCM3 InterPro	335

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ctslb-201 (1) Ensembl	Ensembl	1,351 nt	Select Tool ZFIN BLAST
mRNA	ctslb-203 (1) Ensembl	Ensembl	1,289 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-26g8.4-201 (1) Ensembl	Ensembl	1,348 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-26g8.4-202 (1) Ensembl	Ensembl	308 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ctslb	polyclonal	ctslb	IgG	Rabbit	WB	GeneTex	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations