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Fig. 3 Nkd1 is required for proper DFC migration and KV formation. (A–F) EGFP (Dusp6:d2EGFP) expression in wt (A, C and E) and Nkd1MODFC (B, D and F) embryos; DFCs were assessed at 80% epiboly (A and B), tailbud to 1-somite stage (C and D) and at 8-somite stage (E and F). (G and H) Fluorescence image denoting KV cilia in wt (J) and Nkd1MODFC (K) embryos. Dusp6:d2EGFP (green) and anti-acetylated tubulin (red) indicate cilia in KV cells. (I) Graph of DFC migration defects. N notes the sample size. ** = p < 0.01 compared to uninjected using Fisher′s exact test.
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Reprinted from Developmental Biology, 348(1), Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C., Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning, 22-33, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.