ZFIN Image: Cao et al., 2009, Fig. 4

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Figure Caption

Fig. 4

Depletion of hdac1 can suppress the phenotypes of pkd2 mutants. (A and B) Phenotypes of hdac1/hi1618 mutants on 2 dpf in side views. (A) shows a wild-type (WT) sibling, while (B) shows a mutant embryo (hi1618). (C–E) Injection of hdac1 morpholino can suppress body curvature of pkd2/hi4166 mutants on 2 pdf. (C) shows mutant embryos injected with the five base-pair mismatch control oligo. (D) shows mutant embryos injected with the hdac1 morpholino. (E) shows average curvature angle in embryos injected with control or hdac1 morpholino. n = 5, *, P < 0.05. (F–H) Injection of hdac1 morpholino can suppress kidney cyst formation in pkd2 morphants (pkd2mo) on 3 pdf. 4166: embryos from pkd2/hi4166 heterozygous cross; ctrolMO: embryos injected with control morpholino. HDAC1 MO: embryos injected with hdac1 morpholino.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA