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Fig. S5 Hyperplastic, dysplastic, and degenerative changes in H&E-stained sections of testes from adult brca2Q658X homozygous zebrafish. (A) Testicular tubules are lined by numerous germ cells that form multicellular layers (Inset, long arrow). Multifocally, dysplastic germ cells with large nuclei, vacuolated chromatin, and prominent nucleoli are seen (Inset, short arrow). (B) Testes from brca2Q658X homozygotes show segmental degeneration, with loss of spermatocytes in testicular tubules. (Scale bars: 100 μm in A; 200 μm in B; 50 μm in the Inset in A.)
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Full text @ Proc. Natl. Acad. Sci. USA