ZFIN Image: Shive et al., 2010, Fig. 2

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Fig. 2

Failure of ovarian development occurs in brca2^Q658X homozygotes during gonadal development. (A) Gonads from WT, brca2^Q658X heterozygotes, and brca2^Q658X homozygotes are indistinguishable at 21 dpf. (B) At 31 dpf, WT and brca2^Q658X heterozygotes exhibit juvenile ovaries, early testicular differentiation, or early ovarian differentiation, whereas brca2^Q658X homozygotes exhibit only early testicular differentiation. Perinucleolar oocytes in juvenile ovaries are indicated by short arrows; putative premeiotic germ cells are indicated by arrowheads. (C and D) At 41 and 51 dpf, WT and brca2^Q658X heterozygotes exhibit continued maturation of testes or ovaries, whereas brca2^Q658X homozygotes exhibit only testicular development. go, gonocyte; sgc, spermatogonial cyst; oc, oocyte; sc, spermatocyst; I, stage I oocyte; II, stage II oocyte. (Scale bars: 50 μm; 100 μm in 51 dpf ovaries.)

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Acknowledgments

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