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Fig. S6 Hh-induced downregulation of gli2a is not enhanced by co-injection of rest MO. Lateral view, head and hindbrain of embryos probed for either gli2a (A-D) or nkx2.2a (inserts A′-D′) for comparison. (A, B) gli2a expression in control and age matched rest morphants. C) Overexpression of shh results in decreased levels of gli2a and increased levels of nkx2.2a (C′). (D) Embryos injected with both rest mo and shh mRNA have dramatically enhanced nkx2.2a expression (D′), co-injection does not correspondingly downregulate gli2a expression (D).
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Reprinted from Developmental Biology, 340(2), Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I., The transcriptional repressor REST/NRSF modulates hedgehog signaling, 293-305, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.