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Fig. 5 dlx3b/4b and cv2 are required for PPR marker expression. (A–J) eya1 (A–E) and six4.1 (F–J) expression are reduced in the PPR of Dlx3b/4b (B,G) and Cv2 (C,H) morphants, but can be rescued when Bmp4 is knocked down (D,I) or when cv2 mRNA is ectopically expressed (E,J). (K,L) Ectopic dlx3b or cv2 (red) can induce ectopic eya1 (purple). (M) All cells ectopically expressing the uncleavable form of Cv2, cv2-CM (red), ectopically express eya1 (purple). (A–J) Bud stage embryos; dorsal views, with anterior to the top. (K–M) 80% epiboly embryos; lateral views, with ventral to the left.
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Reprinted from Developmental Biology, 325(1), Esterberg, R., and Fritz, A., dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity, 189-199, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.