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Fig. 8 pax2a expression in the otic placode requires Cv2. (A–E) pax2a expression is lost from the otic placode of Dlx3b/4b (B) and in 69% (27/39) of Cv2 (C,D) morphants. pax2a expression can be restored to the otic placode when cv2 mRNA is ectopically expressed in Dlx3b/4b morphants (E). (A–E) 6-somite embryos; dorsal view, with anterior to the top.
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Reprinted from Developmental Biology, 325(1), Esterberg, R., and Fritz, A., dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity, 189-199, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.