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Fig. S2 shr is required for ventral pancreas development. Confocal projections of wild-type and shrs435 mutant larvae in the Tg(fabp1a:dsRed, elastase:GFP; insulin:dsRed) line at 96 hpf. (A, A′) shrs435 mutant larvae show multiple Tg(elastase: GFP)-positive ventral pancreatic buds (white arrowheads), and defective elongation of the ventral pancreatic tail (white arrow). Despite defective hepatic differentiation, a population of liver cells expresses DsRed in the mutant larvae. All images are ventral views, anterior to the top.
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Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.