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Fig. 1 Skeletal muscle is severely disorganized in ruz mutants. (A) Wild-type fish skeletal muscle is highly birefringent at 5–6 dpf. (B) 5–6 dpf ruz homozygous mutants show decreased skeletal muscle birefringence and, on a TL background, body curvature. (C, D) Longitudinal sections of zebrafish skeletal muscle at 5 dpf were stained with hematoxylin. (C) Wild-type muscle shows myofiber alignment between myosepta and peripherally localized nuclei. (D) ruz muscle myofibers appear unaligned with abnormally shaped nuclei. Arrows indicate myosepta.
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Reprinted from Developmental Biology, 309(2), Steffen, L.S., Guyon, J.R., Vogel, E.D., Howell, M.H., Zhou, Y., Weber, G.J., Zon, L.I., and Kunkel, L.M., The zebrafish runzel muscular dystrophy is linked to the titin gene, 180-192, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.