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Fig. 4 The up-regulation of nkx2.2a expression in the ventral hindbrain that is caused by loss of hdac1 function is strictly smoothened-dependent. Expression of nkx2.2a at 25 hpf in hindbrain of (A) wild-type sibling embryo microinjected with an hdac1 control-MO, (B) homozygous smoothened mutant embryo microinjected with hdac1 control-MO, (C) wild-type sibling embryo microinjected with an hdac1-specific MO and (D) homozygous smoothened mutant embryo microinjected with an hdac1-specific MO. Panels show transverse sections through the hindbrain of 25 hpf embryos at the level of rhombomere 5.
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Reprinted from Mechanisms of Development, 123(1), Cunliffe, V.T., and Casaccia-Bonnefil, P., Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS, 24-30, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.