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Fig. 2 p53 MO Attenuates Apoptosis Induced by MOs and GripNAs, as Detected by TUNEL Assay (A–M) Fluorescent images of 30 hpf embryos injected with indicated MOs and subjected to TUNEL assay to detect apoptosis. A strong fluorescent signal for Smo MO (C), Wnt5 MO1 (E), and Wnt5 GripNA1 (H), similar to Mdm2 MO (L), indicates increased apoptosis. The fluorescent signal is strongly diminished by co-knockdown of p53 (D, F, I, and M), similar to the uninjected control (A), Wnt5 MO2 (G), or Wnt5 mutant (J). Wnt5 mutant is not affected by p53 knockdown (K).
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