ZFIN Image: Chen et al., 2004, Fig. 1

Image

Figure Caption

Fig. 1 Neuronal progenitors in Hi904 mutants differentiate prematurely to cause supernumerary primary neurons at the expense of glia and secondary neurons. (A) BrdU incorporation (gray) and expression of pan-neuronal marker HuC (brown) in cervical spinal cord show premature cell cycle exit and differentiation in the mutant. (B) Anti-Islet1/2 staining of Rohon-Beard neurons (arrow) and primary motoneurons (arrowhead) in trunk spinal cord indicates supernumerary and disorganized primary neurons in the mutant. (C) Zn5 antibody staining of secondary motoneurons (arrowhead) and lateral longitudinal fasciculus (arrow) in trunk spinal cord show the absence of secondary neurons in the mutant. (D) Zrf1 staining of radial glial cells in trunk spinal cord reveals the absence of glial cells in the mutant.

Acknowledgments

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Reprinted from Developmental Biology, 267(2), Chen, W., and Casey Corliss, D., Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis, 361-373, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.