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Fig. S3

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ZDB-IMAGE-060307-13
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Figures for Rentzsch et al., 2006
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Fig. S3 Loss of Cvl2 causes dorsalization and rescues the ventral tail fin duplication of ogon/sizzled (ogo) mutants. (A,C,E,G,I,J) Control embryos, (B,D,F,H,K) cvl2 MO injected. (A-H) Immunostainings or whole-mount in situ hybridization with antibodies or probes indicated in lower left corners. (A-F) Eighty percent epiboly stage, dorsal towards the right. (A,B) Vegetal views of embryos also shown in Fig. 2C,D; (C-F) Lateral views; insets in E,F show lateral views of same embryos. (G, H) Ten-somite stage, dorsal views. In the injected embryo, the anterior somites are laterally expanded. (I-K) Live embryos at 36 hpf, lateral views; insets show magnified ventral views on tail. There is duplication of the ventral tail fin in the ogon mutant (J), which is rescued close to wild-type condition (I) after injection of cvl2 MO (K). The small eyes phenotype of the ogon mutant results from brain necrosis, which is most probably not due to the loss of sizzled, but to a thus far unidentified other gene deleted in the used m60 deficiency allele. Accordingly, it is not rescued upon injection of cvl2 MO.

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