Gene
tbx16l
- ID
- ZDB-GENE-980526-171
- Name
- T-box transcription factor 16, like
- Symbol
- tbx16l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within paraxial mesoderm formation and somite development. Predicted to be located in nucleus. Is expressed in embryonic structure; hematopoietic system; mesoderm; and post-vent region. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 73 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb123 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Morrow et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 5 | Alliance | Spondylocostal dysostosis 5 | 122600 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
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Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:P79742
|
473 | |||||
|
UniProtKB:A0A8M6Z0I2
|
376 | |||||
|
UniProtKB:A0A8M6YZ11
|
492 | |||||
|
UniProtKB:A0A8M1PB76
|
473 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tbx16l-201
(1)
|
Ensembl | 3,080 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207C6 | ZFIN Curated Data | |
| Encodes | EST | cb123 | ||
| Encodes | cDNA | MGC:109816 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131052 (1) | 2847 nt | ||
| Genomic | GenBank:BX548073 (2) | 222583 nt | ||
| Polypeptide | UniProtKB:A0A8M6YZ11 (1) | 492 aa |
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Tsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, K.I., Ohba, Y., Koo, B.K., Hatakeyama, S. (2020) A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Nature communications. 11:4586
- An, S., Ma, L., Wan, L. (2019) TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data. BMC Genomics. 20:224
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Jiang, J., Tang, S., Xia, J., Wen, J., Chen, S., Shu, X., Huen, M.S.Y., Deng, Y. (2018) C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 37(22):2992-3005
- Klatt Shaw, D., Gunther, D., Jurynec, M.J., Chagovetz, A.A., Ritchie, E., Grunwald, D.J. (2018) Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling. Developmental Cell. 45(4):512-525.e5
- Wong, K.L., Akiyama, R., Bessho, Y., Matsui, T. (2018) ERK Activity Dynamics during Zebrafish Embryonic Development. International Journal of Molecular Sciences. 20(1)
- Xing, Y.Y., Cheng, X.N., Li, Y.L., Zhang, C., Saquet, A., Liu, Y.Y., Shao, M., Shi, D.L. (2018) Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements. PLoS Genetics. 14:e1007551
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