Gene
cpeb1b
- ID
- ZDB-GENE-990927-1
- Name
- cytoplasmic polyadenylation element binding protein 1b
- Symbol
- cpeb1b Nomenclature History
- Previous Names
-
- cepb1b
- fd15c06
- wu:fd15c06 (1)
- zorba
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to organonitrogen compound; negative regulation of cytoplasmic translation; and positive regulation of mRNA polyadenylation. Predicted to act upstream of or within mRNA processing and regulation of translation. Part of protein-containing complex. Is expressed in blastomere; germ line cell; nervous system; and notochord. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55829 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026113Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21054 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko2197A | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR032292 | Cytoplasmic polyadenylation element-binding protein 1, N-terminal |
| Domain | IPR032296 | Cytoplasmic polyadenylation element-binding protein, ZZ domain |
| Domain | IPR034977 | CPEB-1, RNA recognition motif 1 |
| Family | IPR034819 | Cytoplasmic polyadenylation element-binding protein |
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Domain Details Per Protein
| Protein | Length | CEBP, ZZ domain superfamily | CPEB-1, RNA recognition motif 1 | Cytoplasmic polyadenylation element-binding protein | Cytoplasmic polyadenylation element-binding protein 1, N-terminal | Cytoplasmic polyadenylation element-binding protein, ZZ domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9YGX5
|
559 | ||||||||
|
UniProtKB:A0A8M9Q7I0
|
554 | ||||||||
|
UniProtKB:A2CE67
|
559 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cpeb1b-201
(1)
|
Ensembl | 663 nt | ||
| mRNA |
cpeb1b-202
(1)
|
Ensembl | 2,912 nt | ||
| ncRNA |
cpeb1b-003
(1)
|
Ensembl | 965 nt | ||
| ncRNA |
cpeb1b-004
(1)
|
Ensembl | 763 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cpeb1b | polyclonal | Rabbit |
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231O17 | ZFIN Curated Data | |
| Contains | SNP | rs3728089 | Stickney et al., 2002 | |
| Contains | SNP | rs3728090 | Stickney et al., 2002 | |
| Contains | SNP | rs3728091 | Stickney et al., 2002 | |
| Contains | SNP | rs3728092 | ZFIN Curated Data | |
| Encodes | EST | fd15c06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55829 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191213 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131427 (1) | 2914 nt | ||
| Genomic | GenBank:BX663612 (1) | 181415 nt | ||
| Polypeptide | UniProtKB:A2CE67 (1) | 559 aa |
- Heng, J., Shi, B., Zhou, J.Y., Zhang, Y., Ma, D., Yang, Y.G., Liu, F. (2023) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2212212120e2212212120
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Vejnar, C.E., Abdelmessih, M., Takacs, C., Yartseva, V., Oikonomou, P., Christiano, R., Stoeckius, M., Lau, S., Lee, M., Beaudoin, J.D., Musaev, D., Darwich-Codore, H., Walther, T., Tavazoie, S., Cifuentes, D., Giraldez, A. (2019) Genome wide analysis of 3'-UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome research. 29(7):1100-1114
- Dingare, C., Niedzwetzki, A., Klemmt, P.A., Godbersen, S., Fuentes, R., Mullins, M.C., Lecaudey, V. (2018) The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish. Development (Cambridge, England). 145(22):
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Du, T.T., Xu, P.F., Dong, Z.W., Fan, H.B., Jin, Y., Dong, M., Chen, Y., Pan, W.J., Ren, R.B., Liu, T.X., Deng, M., Huang, Q.H. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Developmental Biology. 392(2):233-44
- Vanhauwaert, S., Van Peer, G., Rihani, A., Janssens, E., Rondou, P., Lefever, S., De Paepe, A., Coucke, P.J., Speleman, F., Vandesompele, J., Willaert, A. (2014) Expressed Repeat Elements Improve RT-qPCR Normalization across a Wide Range of Zebrafish Gene Expression Studies. PLoS One. 9:e109091
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Suzuki, H., Tsukahara, T., and Inoue, K. (2009) Localization of c-mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba. Bioscience trends. 3(3):96-104
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