Gene

gfap

ID

ZDB-GENE-990914-3

Name

glial fibrillary acidic protein

Symbol

gfap Nomenclature History

Previous Names

af506734 (1)
cb345 (1)
etID36982.3 (1)
wu:fb34h11 (1)
wu:fk42c12
xx:af506734 (1)
zgc:110485
zrf-1 antigen (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have structural molecule activity. Localizes to cytoplasm and type III intermediate filament. Human ortholog(s) of this gene implicated in Alexander disease. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Orthologous to human GFAP (glial fibrillary acidic protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

119 figures from 80 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb345 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gfap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Alexander disease	Alliance	Alexander disease	203450

Associated With gfap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR006821	Intermediate filament head, DNA-binding domain
Domain	IPR039008	Intermediate filament, rod domain
Family	IPR002957	Keratin, type I
Family	IPR050405	Intermediate filament structural protein

Domain Details Per Protein

Protein	Length	Intermediate filament head, DNA-binding domain	Intermediate filament protein, conserved site	Intermediate filament, rod domain	Intermediate filament structural protein	Keratin, type I
UniProtKB:Q58EE9 InterPro	444
UniProtKB:F1RAE8 InterPro	444
UniProtKB:B2GP50 InterPro	444

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gfap-201 (1) Ensembl	Ensembl		2,651 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-gfap	monoclonal	gfap	IgG1	Mouse	IHC	Dako North America, Inc. Abcam plc MP Biomedicals	3
zrf-1	monoclonal	gfap	IgG1	Mouse	IHC	Zebrafish International Resource Center (ZIRC) ( order this )	136
Ab21-gfap	polyclonal	gfap	IgG	Rabbit	WB	NSJ Bioreagents	2
Ab2-gfap	polyclonal	gfap		Rabbit	IHC	Dako North America, Inc.	45
Ab4-gfap	polyclonal	gfap		Rabbit	IHC		6

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations