Gene

tenm3

ID

ZDB-GENE-990714-19

Name

teneurin transmembrane protein 3

Symbol

tenm3 Nomenclature History

Previous Names

cb399 (1)
id:ibd3379
odd Oz/ten-m homolog 3 (1)
odz3 (1)
seizure resistant s334 (1)
srs334 (1)
tenascin-M3 (1)
zgc:153720

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within dendrite guidance; retinal ganglion cell axon guidance; and visual perception. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including fin bud; immature eye; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in syndromic microphthalmia. Orthologous to human TENM3 (teneurin transmembrane protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb399 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tenm3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Microphthalmia, syndromic 15	615145
		?Microphthalmia/coloboma 9	615145

Associated With tenm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR009471	Teneurin intracellular, N-terminal
Domain	IPR022385	Rhs repeat-associated core
Domain	IPR028916	Tox-GHH domain
Family	IPR051216	Teneurin domain-containing protein
Homologous_superfamily	IPR008969	Carboxypeptidase-like, regulatory domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR006530	YD repeat
Repeat	IPR031325	RHS repeat

Domain Details Per Protein

Protein	Length	Carboxypeptidase-like, regulatory domain superfamily	EGF-like domain	RHS repeat	Rhs repeat-associated core	Six-bladed beta-propeller, TolB-like	Teneurin domain-containing protein	Teneurin intracellular, N-terminal	Tox-GHH domain	YD repeat
UniProtKB:Q9W7R4 InterPro	2694

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tenm3-201 (1) Ensembl	Ensembl	1,469 nt	Select Tool ZFIN BLAST
mRNA	tenm3-202 (1) Ensembl	Ensembl	8,515 nt	Select Tool ZFIN BLAST
mRNA	tenm3-204 (1) Ensembl	Ensembl	11,289 nt	Select Tool ZFIN BLAST
mRNA	tenm3-206 (1) Ensembl	Ensembl	8,719 nt	Select Tool ZFIN BLAST
mRNA	tenm3-207 (1) Ensembl	Ensembl	2,890 nt	Select Tool ZFIN BLAST
ncRNA	tenm3-203 (1) Ensembl	Ensembl	627 nt	Select Tool ZFIN BLAST
ncRNA	tenm3-205 (1) Ensembl	Ensembl	653 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tenm3		tenm3		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations