Gene
opn1mw1
- ID
- ZDB-GENE-990604-42
- Name
- opsin 1 (cone pigments), medium-wave-sensitive, 1
- Symbol
- opn1mw1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within signal transduction and visual perception. Located in photoreceptor outer segment. Is expressed in several structures, including endocrine system; heart; integument; photoreceptor cell; and visual system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14284 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Rhodopsin | Rhodopsin, N-terminal | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W6A5
|
349 | |||||||
|
UniProtKB:A0A0N9NXZ8
|
349 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn1mw1-201
(1)
|
Ensembl | 1,574 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-opn1mw1 | polyclonal | Mouse |
|
ABclonal
|
2 | ||
| Ab1-opn1mw1 | polyclonal | Rabbit |
|
27 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-263A23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73052 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131253 (1) | 1579 nt | ||
| Genomic | GenBank:AL732567 (1) | 152840 nt | ||
| Polypeptide | UniProtKB:A0A0N9NXZ8 (1) | 349 aa |
No data available
- Fagundes, T., Pannetier, P., Gölz, L., Behnstedt, L., Morthorst, J., Vergauwen, L., Knapen, D., Holbech, H., Braunbeck, T., Baumann, L. (2024) The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?. Aquatic toxicology (Amsterdam, Netherlands). 272:106969106969
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Yang, H.Z., Zhuo, D., Huang, Z., Luo, G., Liang, S., Fan, Y., Zhao, Y., Lv, X., Qiu, C., Zhang, L., Liu, Y., Sun, T., Chen, X., Li, S.S., Jin, X. (2024) Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Investigative ophthalmology & visual science. 65:3131
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Wang, Y.Y., Liang, X.F., Lu, K. (2023) Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Gene. 897:148059
- Zhang, J., Jing, M., Li, P., Sun, L., Pi, X., Jiang, N., Zhu, K.K., Li, H., Li, J., Wang, M., Zhang, J., Liu, M., Mu, H., Hu, Y., Cui, X. (2023) Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1869(4):166645
- Li, Y., Chen, Q., Liu, Y., Bi, L., Jin, L., Xu, K., Peng, R. (2022) High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis. Apoptosis : an international journal on programmed cell death. 27(7-8):509-520
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