Gene

pgr

ID

ZDB-GENE-990415-214

Name

progesterone receptor

Symbol

pgr Nomenclature History

Previous Names

gb:dq017620
NR3C3 (1)
pr

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits steroid binding activity and steroid hormone receptor activity. Involved in luteinizing hormone signaling pathway and ovulation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Is expressed in several structures, including brain; digestive system; gonad; steroid hormone secreting cell; and ventricular zone. Orthologous to human PGR (progesterone receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

dq017620 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pgr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Progesterone resistance	264080

Associated With pgr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001723	Nuclear hormone receptor
Family	IPR050200	Nuclear hormone receptor family NR3 subfamily
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily