Gene

nras

ID

ZDB-GENE-990415-166

Name

NRAS proto-oncogene, GTPase

Symbol

nras Nomenclature History

Previous Names

etID18709.8 (1)
fj99a10
wu:fj99a10 (1)
zgc:100761
zras-b1 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nras Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 4	Alliance	?RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic	614470
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
epidermal nevus	Alliance	Epidermal nevus, somatic	162900
follicular thyroid carcinoma	Alliance	Thyroid carcinoma, follicular, somatic	188470
large congenital melanocytic nevus	Alliance	Melanocytic nevus syndrome, congenital, somatic	137550
linear nevus sebaceous syndrome	Alliance	Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic	163200
Noonan syndrome 6	Alliance	Noonan syndrome 6	613224
		Neurocutaneous melanosis, somatic	249400

Associated With nras Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR020849	Small GTPase, Ras-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase