Gene

mef2aa

ID

ZDB-GENE-990415-163

Name

myocyte enhancer factor 2aa

Symbol

mef2aa Nomenclature History

Previous Names

mef2a
etID309779.18 (1)
wu:fd19d02

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including myofibril assembly; positive regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to localize to nuclear chromatin. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is expressed in cardiovascular system; myotome; nervous system; pharyngeal arch; and somite. Orthologous to human MEF2A (myocyte enhancer factor 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55208 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mef2aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
coronary artery disease	Alliance	{Coronary artery disease, autosomal dominant, 1}	608320

Associated With mef2aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002100	Transcription factor, MADS-box
Domain	IPR022102	Holliday junction regulator protein family C-terminal
Domain	IPR033896	MADS MEF2-like
Family	IPR050142	MADS-box/MEF2 Transcription Factor
Homologous_superfamily	IPR036879	Transcription factor, MADS-box superfamily

Domain Details Per Protein

Protein	Length	Holliday junction regulator protein family C-terminal	MADS-box/MEF2 Transcription Factor	MADS MEF2-like	Transcription factor, MADS-box	Transcription factor, MADS-box superfamily
UniProtKB:A0A8M9PPZ2 InterPro	466
UniProtKB:A0A0R4IRM3 InterPro	460
UniProtKB:Q1LXH6 InterPro	458
UniProtKB:A0A8M9P9W4 InterPro	467
UniProtKB:A0A8M2B5M2 InterPro	503
UniProtKB:A0A8M9PLW4 InterPro	511
UniProtKB:A0A8M2B5Z6 InterPro	504
UniProtKB:A0A8M9PF86 InterPro	512
UniProtKB:A0A8M9PF89 InterPro	467
UniProtKB:A0A8M9P0X9 InterPro	468

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mef2aa-201 (1) Ensembl	Ensembl	1,736 nt	Select Tool
mRNA	mef2aa-202 (1) Ensembl	Ensembl	1,844 nt	Select Tool
mRNA	mef2aa-204 (1) Ensembl	Ensembl	1,733 nt	Select Tool
mRNA	mef2aa-205 (1) Ensembl	Ensembl	2,113 nt	Select Tool
mRNA	mef2aa-206 (1) Ensembl	Ensembl	2,103 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-207 (1) Ensembl	Ensembl	2,124 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-208 (1) Ensembl	Ensembl	1,873 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-209 (1) Ensembl	Ensembl	1,963 nt	Select Tool ZFIN BLAST
ncRNA	mef2aa-005 (1) Ensembl	Ensembl	606 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-mef2	polyclonal	mef2aa mef2ca mef2cb mef2d	IgG	Rabbit	IHC	AnaSpec	5

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations