Gene
en2b
- ID
- ZDB-GENE-980526-40
- Name
- engrailed homeobox 2b
- Symbol
- en2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in autistic disorder. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Orthologous to human EN2 (engrailed homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141696 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000047 | Helix-turn-helix motif |
Conserved_site | IPR017970 | Homeobox, conserved site |
Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
Domain | IPR000747 | Homeodomain engrailed |
Domain | IPR001356 | Homeodomain |
Domain | IPR019549 | Homeobox engrailed, C-terminal |
Domain | IPR020479 | Homeodomain, metazoa |
Family | IPR050720 | Engrailed Homeobox Transcription Factors |
Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
Protein | Length | Engrailed Homeobox Transcription Factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeodomain | Homeodomain engrailed | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:P31533
|
261 |
Interactions and Pathways
No data available
Plasmids
No data available