Gene
cdh11
- ID
- ZDB-GENE-980526-170
- Name
- cadherin 11, type 2, OB-cadherin (osteoblast)
- Symbol
- cdh11 Nomenclature History
- Previous Names
-
- cdhvn
- ventral neural cadherin
- vnc
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within otolith development; retina development in camera-type eye; and retinal ganglion cell axon guidance. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in cleithrum; nervous system; optic vesicle; and pectoral fin bud. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome and Teebi hypertelorism syndrome 2. Orthologous to human CDH11 (cadherin 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| el520 | Allele with one deletion | Unknown | Unknown | TALEN | |
| mn0010Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14413 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27024 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa31589 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Elsahy-Waters syndrome | Alliance | Elsahy-Waters syndrome | 211380 |
| Teebi hypertelorism syndrome 2 | Alliance | Teebi hypertelorism syndrome 2 | 619736 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DGG4
|
800 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-155A19 | ZFIN Curated Data | |
| Encodes | EST | wz12628 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194061 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194085 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194941 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131214 (1) | 2741 nt | ||
| Genomic | GenBank:CT025913 (2) | 192923 nt | ||
| Polypeptide | UniProtKB:B3DGG4 (1) | 800 aa |
- Tang, W.J., Watson, C.J., Olmstead, T., Allan, C.H., Kwon, R.Y. (2022) Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration. iScience. 25:103784
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Kikel-Coury, N.L., Brandt, J.P., Correia, I.A., O'Dea, M.R., DeSantis, D.F., Sterling, F., Vaughan, K., Ozcebe, G., Zorlutuna, P., Smith, C.J. (2021) Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. PLoS Biology. 19:e3001444
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Knüfer, A., Diana, G., Walsh, G.S., Clarke, J.D., Guthrie, S. (2020) Cadherins regulate nuclear topography and function of developing ocular motor circuitry. eLIFE. 9:
- Lu, J., Liu, R., Miao, A., Chen, X., Xiao, W., Wang, Y., Cao, D., Pan, J., Li, L., Luo, Y. (2020) The role of cldnh during the early retinal development in zebrafish. Experimental Eye Research. 200:108207
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Kindt, L.M., Coughlin, A.R., Perosino, T.R., Ersfeld, H., Hampton, M., Liang, J.O. (2018) Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing. Genesis (New York, N.Y. : 2000). 56(3):e23096
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
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