Gene

rptor

ID

ZDB-GENE-130530-685

Name

regulatory associated protein of MTOR, complex 1

Symbol

rptor Nomenclature History

Previous Names

zmp:0000000682 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have protein binding activity, bridging. Predicted to be involved in several processes, including TOR signaling; cellular response to amino acid stimulus; and positive regulation of protein serine/threonine kinase activity. Predicted to localize to TORC1 complex and cytoplasm. Is expressed in head; notochord; post-vent region; pronephros; and spinal cord. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from Tucker et al., 2024
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rptor Human Ortholog

No data available

Associated With rptor Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR029347	Raptor, N-terminal CASPase-like domain
Family	IPR004083	Regulatory associated protein of TOR
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR000357	HEAT repeat
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	HEAT repeat	Raptor, N-terminal CASPase-like domain	Regulatory associated protein of TOR	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A0R4IFI0 InterPro	1363
UniProtKB:A0A8M6Z171 InterPro	1350

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rptor-201 (1) Ensembl	Ensembl	4,489 nt	Select Tool ZFIN BLAST
mRNA	rptor-202 (1) Ensembl	Ensembl	4,638 nt	Select Tool
mRNA	rptor-203 (1) Ensembl	Ensembl	4,441 nt	Select Tool ZFIN BLAST
mRNA	rptor-204 (1) Ensembl	Ensembl	4,342 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-rptor	monoclonal	rptor		Rabbit	WB	Cell Signaling Technology, Inc.	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations