Gene

lrp4

ID

ZDB-GENE-130129-1

Name

low density lipoprotein receptor-related protein 4

Symbol

lrp4 Nomenclature History

Previous Names

eni
nui

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in axon regeneration; establishment of synaptic specificity at neuromuscular junction; and neuromuscular synaptic transmission. Predicted to localize to integral component of membrane. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Orthologous to human LRP4 (LDL receptor related protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cenani-Lenz syndactyly syndrome	Alliance	Cenani-Lenz syndactyly syndrome	212780
congenital myasthenic syndrome 17	Alliance	?Myasthenic syndrome, congenital, 17	616304
sclerosteosis 2	Alliance	Sclerosteosis 2	614305

Associated With lrp4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
bone development disease	AB + MO1-lrp4	control	Tian et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR050778	Cueball/EGF/LRP/Nidogen
Family	IPR051221	Low-density lipoprotein receptor-related
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Cueball/EGF/LRP/Nidogen	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Low-density lipoprotein receptor-related	NOTCH1 EGF-like calcium-binding domain	Six-bladed beta-propeller, TolB-like
UniProtKB:A0A2R8PYI8 InterPro	968
UniProtKB:A0A8M6Z1W5 InterPro	1913

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-lrp4	monoclonal	lrp4		Mouse	IHC	Abcam plc	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations