Gene

kif21a

ID

ZDB-GENE-110411-237

Name

kinesin family member 21A

Symbol

kif21a Nomenclature History

Previous Names

si:ch1073-222m2.1
si:ch211-114o15.1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles. Orthologous to human KIF21A (kinesin family member 21A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Riedmann et al., 2023

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Riedmann et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif21a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital fibrosis of the extraocular muscles 1	Alliance	Fibrosis of extraocular muscles, congenital, 1	135700
congenital fibrosis of the extraocular muscles 1	Alliance	Fibrosis of extraocular muscles, congenital, 3B	135700

Associated With kif21a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Kinesin-like protein	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Quinoprotein alcohol dehydrogenase-like superfamily	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3AWT6 InterPro	1591
UniProtKB:A0A8M3APB0 InterPro	1575
UniProtKB:A0A8M2BAB6 InterPro	1597
UniProtKB:F8W409 InterPro	1598
UniProtKB:A0A8M9PNH0 InterPro	1597
UniProtKB:A0A8M2BAD0 InterPro	1554

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kif21a-201 (1) Ensembl	Ensembl		8,220 nt	Select Tool
mRNA	kif21a-202 (1) Ensembl	Ensembl		4,584 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-kif21a	polyclonal	kif21a	IgG	Rabbit	IHC WB	Biorbyt LLC	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations