Gene
sost
- ID
- ZDB-GENE-110411-139
- Name
- sclerostin
- Symbol
- sost Nomenclature History
- Previous Names
-
- si:dkeyp-44b3.1
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant craniodiaphyseal dysplasia | Alliance | Craniodiaphyseal dysplasia, autosomal dominant | 122860 |
| sclerosteosis 1 | Alliance | Sclerosteosis 1 | 269500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine knot, C-terminal | Cystine-knot cytokine | Sclerostin/Sclerostin domain-containing protein 1 |
|---|---|---|---|---|
|
UniProtKB:A0A8M1PZF1
|
210 | |||
|
UniProtKB:E7EXX7
|
210 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-44B3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001340647 (1) | |||
| Genomic | GenBank:CR932037 (1) | 151672 nt | ||
| Polypeptide | UniProtKB:A0A8M1PZF1 (1) | 210 aa |
- Breuer, M., Rummler, M., Singh, J., Maher, S., Zaouter, C., Jamadagni, P., Pilon, N., Willie, B.M., Patten, S.A. (2024) CHD7 regulates craniofacial cartilage development via controlling HTR2B expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 39(4):498-512
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Diamond, K.M., Burtner, A.E., Siddiqui, D., Alvarado, K., Leake, S., Rolfe, S., Zhang, C., Kwon, R.Y., Maga, A.M. (2023) Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases. Journal of anatomy. 243(1):66-77
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Pagán, A.J., Lee, L.J., Edwards-Hicks, J., Moens, C.B., Tobin, D.M., Busch-Nentwich, E.M., Pearce, E.L., Ramakrishnan, L. (2022) mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 185(20):3720-3738.e13
- Sojan, J.M., Gioacchini, G., Giorgini, E., Orlando, P., Tiano, L., Maradonna, F., Carnevali, O. (2022) Zebrafish caudal fin as a model to investigate the role of probiotics in bone regeneration. Scientific Reports. 12:8057
- Xu, P., Lin, B., Deng, X., He, S., Chen, N., Wang, N. (2022) Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Journal of ethnopharmacology. 293:115269
- Kozak, E.L., Palit, S., Miranda-Rodríguez, J.R., Janjic, A., Böttcher, A., Lickert, H., Enard, W., Theis, F.J., López-Schier, H. (2020) Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Current biology : CB. 30(6):1142-1151.e6
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