Gene
sost
- ID
- ZDB-GENE-110411-139
- Name
- sclerostin
- Symbol
- sost Nomenclature History
- Previous Names
-
- si:dkeyp-44b3.1
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant craniodiaphyseal dysplasia | Alliance | Craniodiaphyseal dysplasia, autosomal dominant | 122860 |
| sclerosteosis 1 | Alliance | Sclerosteosis 1 | 269500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine knot, C-terminal | Cystine-knot cytokine | Sclerostin/Sclerostin domain-containing protein 1 |
|---|---|---|---|---|
|
UniProtKB:A0A8M1PZF1
|
210 | |||
|
UniProtKB:E7EXX7
|
210 |
Interactions and Pathways
No data available
Plasmids
No data available