Gene
rxfp2b
- ID
- ZDB-GENE-110408-27
- Name
- relaxin family peptide receptor 2b
- Symbol
- rxfp2b Nomenclature History
- Previous Names
-
- rxfp2a
- si:dkey-1o1.1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled peptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and hormone-mediated signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in cryptorchidism. Is expressed in female organism; male organism; and ovary. Orthologous to human RXFP2 (relaxin family peptide receptor 2).
- Genome Resources
- Note
-
In March of 2012 this gene was found to be orthologous (both AA and synteny) to human and mouse RXFP2. The curator named this gene rxfp2a, in accordance with Zebrafish Nomenclature Guidelines. In the same month, Yegorov and Good (2012) named this gene rxpfb. Subsequently, two additional publications have maintained Yegorov and Good's nomenclature. In November of 2015 the names and gene symbols of both paralogs were changed to reflect a request filed with NCBI that was forwarded to the ZFIN nomenclature coordinator.
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR008112 | Relaxin receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | LDL receptor-like superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Relaxin receptor |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W5N7
|
750 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rxfp2b-204
(1)
|
Ensembl | 2,523 nt | ||
| mRNA |
rxfp2b-203
(1)
|
Ensembl | 2,510 nt | ||
| mRNA |
rxfp2b-205
(1)
|
Ensembl | 1,443 nt | ||
| ncRNA |
rxfp2b-003
(1)
|
Ensembl | 516 nt | ||
| ncRNA |
rxfp2b-004
(1)
|
Ensembl | 436 nt |
Interactions and Pathways
No data available
Plasmids
No data available