Gene
rigi
- ID
- ZDB-GENE-090821-7
- Name
- RNA sensor RIG-I
- Symbol
- rigi Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to have ATP binding activity; DNA binding activity; and hydrolase activity. Involved in I-kappaB kinase/NF-kappaB signaling; defense response to other organism; and regulation of transcription, DNA-templated. Localizes to cytosol and nucleus. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human DDX58 (DExD/H-box helicase 58).
- Genome Resources
-
- Alliance (1)
- Gene:100333797 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Wang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Singleton-Merten syndrome 2 | 616298 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR021673 | RIG-I-like receptor, C-terminal regulatory domain |
| Domain | IPR031964 | Caspase recruitment domain |
| Domain | IPR041204 | RIG-I-like receptor, C-terminal |
| Domain | IPR042145 | RIG-I, CARD domain repeat 2 |
| Family | IPR051363 | RIG-I-like Receptor (RLR) Helicase |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038557 | RIG-I-like receptor, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Caspase recruitment domain | DEAD/DEAH box helicase domain | Death-like domain superfamily | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RIG-I, CARD domain repeat 2 | RIG-I-like receptor, C-terminal | RIG-I-like receptor, C-terminal domain superfamily | RIG-I-like receptor, C-terminal regulatory domain | RIG-I-like Receptor (RLR) Helicase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0D5W690
|
937 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance