Gene
cd40
- ID
- ZDB-GENE-090313-95
- Name
- CD40 molecule, TNF receptor superfamily member 5
- Symbol
- cd40 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Exhibits CD154 receptor binding activity. Involved in TRIF-dependent toll-like receptor signaling pathway. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; arthritis (multiple); autoimmune hypersensitivity disease (multiple); hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human CD40 (CD40 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gong et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency with hyper IgM type 3 | Alliance | Immunodeficiency with hyper-IgM, type 3 | 606843 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor Necrosis Factor Receptor Superfamily Member 5 |
|---|---|---|---|
|
UniProtKB:B8X730
|
286 |
Interactions and Pathways
No data available
Plasmids
No data available