Gene
fbxw7
- ID
- ZDB-GENE-090313-79
- Name
- F-box and WD repeat domain containing 7
- Symbol
- fbxw7 Nomenclature History
- Previous Names
-
- si:ch211-208n2.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within angiogenesis; negative regulation of myelination; and regulation of signal transduction. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in glioblast (sensu Vertebrata); neural tube; neuroblast (sensu Vertebrata); spinal cord; and trunk. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021059Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028110Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| stl64 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| vu56 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fbxw7 | N/A | (2) |
| MO2-fbxw7 | N/A | Izumi et al., 2012 |
| MO3-fbxw7 | N/A | Izumi et al., 2012 |
| MO4-fbxw7 | N/A | Wang et al., 2013 |
| MO5-fbxw7 | N/A | Wang et al., 2013 |
| MO6-fbxw7 | N/A | Wang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental delay, hypotonia, and impaired language | Alliance | Developmental delay, hypotonia, and impaired language | 620012 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001810 | F-box domain |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036047 | F-box-like domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | F-box domain | F-box-like domain superfamily | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B7ZDC8
|
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UniProtKB:B8A474
|
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UniProtKB:F1RCB5
|
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|
UniProtKB:A0A8M9Q490
|
834 | |||||||
|
UniProtKB:A0A8M9Q0J4
|
761 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-373L24 | ZFIN Curated Data | |
| Contained in | BAC | CH211-208N2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-104E13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005170948 (1) | 4922 nt | ||
| Genomic | RefSeq:NW_018394483 (1) | |||
| Polypeptide | UniProtKB:A0A8M9PIU0 (1) | 835 aa |
- Lee, S.H., So, J., Shin, D. (2023) Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish. Hepatology (Baltimore, Md.). 77(4):1198-1210
- Wang, B., Xu, M., Li, M., Wu, F., Hu, S., Chen, X., Zhao, L., Huang, Z., Lan, F., Liu, D., Wang, Y. (2020) miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7. Molecular therapy. Nucleic acids. 19:1299-1308
- Ko, S., Russell, J.O., Tian, J., Gao, C., Kobayashi, M., Feng, R., Yuan, X., Shao, C., Ding, H., Poddar, M., Singh, S., Locker, J., Weng, H.L., Monga, S.P., Shin, D. (2018) Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8. Gastroenterology. 156(1):187-202.e14
- Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kearns, C.A., Ravanelli, A.M., Cooper, K., Appel, B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14861-71
- Roberto, V.P., Tiago, D.M., Gautvik, K., Cancela, M.L. (2015) Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 566(1):54-62
- Blackburn, J.S., Liu, S., Wilder, J.L., Dobrinski, K.P., Lobbardi, R., Moore, F.E., Martinez, S.A., Chen, E.Y., Lee, C., Langenau, D.M. (2014) Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 25:366-78
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, R., Wang, Y., Liu, N., Ren, C., Jiang, C., Zhang, K., Yu, S., Chen, Y., Tang, H., Deng, Q., Fu, C., Wang, Y., Li, R., Liu, M., Pan, W., and Wang, P. (2013) FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research. 23(6):803-19
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