Gene
lmod3
- ID
- ZDB-GENE-090313-353
- Name
- leiomodin 3 (fetal)
- Symbol
- lmod3 Nomenclature History
- Previous Names
-
- si:dkey-90a13.2
- si:dkey-90a13.7 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable actin monomer binding activity and tropomyosin binding activity. Acts upstream of or within muscle contraction and skeletal muscle thin filament assembly. Predicted to be located in M band and cytoskeleton. Predicted to be active in striated muscle thin filament. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Berger et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nemaline myopathy 10 | Alliance | Nemaline myopathy 10 | 616165 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nemaline myopathy | AB + MO1-lmod3 + MO2-lmod3 | standard conditions | Yuen et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Leucine-rich repeat domain superfamily | Tropomodulin |
|---|---|---|---|
|
UniProtKB:A0A2R8QDE5
|
670 | ||
|
UniProtKB:A0A8M9QA08
|
670 | ||
|
UniProtKB:E7F7X0
|
670 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-lmod3 | polyclonal | IgG | Rabbit |
|
Proteintech
|
2 |
Plasmids
No data available