Gene
lepa
- ID
- ZDB-GENE-081001-1
- Name
- leptin a
- Symbol
- lepa Nomenclature History
- Previous Names
-
- lep
- ob (1)
- si:dkey-98o11.2
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have hormone activity. Involved in camera-type eye development; inner ear development; and nervous system development. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Is expressed in several structures, including brain; digestive system; heart; integument; and pleuroperitoneal region. Orthologous to human LEP (leptin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital leptin deficiency | Alliance | Obesity, morbid, due to leptin deficiency | 614962 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Leptin |
|---|---|---|---|
|
UniProtKB:Q0D250
|
166 |
Interactions and Pathways
No data available
Plasmids
No data available